I managed to get DiscoverMedia2_EU-AS_2110_V18 working on my Golf 7.5 2019 Discover Media with 16 GB VAG SD card by doing below changes to the package. Hopefully following can be applied to other MIB2 platforms.
Removing unnecessary brand folders and files from mapcfg-folder and extra languages from sds-folder was not enough to make the package fit to the 16 GB card. Unluckily the navigation did not run if files were brutely deleted from region nds-folders. Instead of deleting files from nds-folders I decided to replace big files of irrelevant (to me) region with smaller files of some other region. This seemed to keep the system satisfied and so far the navigation has worked normally. When the next update comes and the package grows even bigger I will probably just select a second not-so-relevant region to tamper with.
Delete:
\maps\00\cfg\mapcfg\SEAT
\maps\00\cfg\mapcfg\SKODA
\maps\00\cfg\mapcfg\se_default.cfg
\maps\00\cfg\mapcfg\sk_default.cfg
\maps\00\sds\ - all folders except FI, SE and GB
\maps\00\nds\PRODUCT\E10\ROUTING.NDS
Copy:
\maps\00\nds\PRODUCT\E13\ROUTING.NDS to folder \maps\00\nds\PRODUCT\E10\
Depending on your own region you can choose to replace the ROUTING.NDS of some other region. For me E10 was the most irrelevant and ROUTING.NDS from E13 was small enough to get the package to fit the SD card. I found the region codes from: https://www.skodacommunity.de/threads/navikarten-update-q1-2022-release-2023-fuer-mib1-mib2.103181/page-186