I have an Octavia sport (a new one) and the stereo is orientated well over to the right and is quite uncomfortable. It doesn't seem to make a great deal of difference what I do. So, I was going to try and disconnect the rear tweeters to see if that helps.

They are by the door handle, so I prised out the window switch (which has the tweeter cover on it), removed the only screw I could see but still couldn't get access to the connections. It is possible to get your finger behind but I am loath to do this in case I damage something.

Does anyone know how to make the stereo more evenly balanced and if it is the tweeter trick, how do I get to the back of the tweeter?

Use the balance, Fader and Audio settings to change the sound to how you like it?