Octavia 1.2tsi estate, long story but

Will this combination be ok?

2 x Goodyear Vector 4seasons gen2 (directional) on front

2 x Vredestein Quatrac 5 (Asymmetric) on rear

Directional on front or rear?

Goodyears are wetgrip B, Vredestein wetgrip C

Or asking for trouble?

I'd put the directionals on the front if the tread depths are about the same.  If there's a significant difference, put the new(er) ones on the rear.