I have been repairing my punctures with tyre plugs for 18 years now, never had one fail, all the tyres have continued to wear to the legal limit like the others before replacement and have never been an issue at the CT tests.
They do stick out a bit or at least become more visible as the tyre wears, the only time it was ever a problem was when I sold a car and the new owner, a Brit who knew nothing of the regulations or life in France after 2 decades was outraged to find it.
I would say conservatively I have avoided replacing 10 tyres because most tyre fitting garages here come out with the nonsense that they are not allowed to do puncture repairs and that they have to replace both tyres on the same axle.
The Yeti not having a spare wheel my tyre plug kit is even more important to me than ever, I also have a mushroom plug insertion tool kit but have yet to use it, unless the puncture is on the outside edge of a front wheel giving enough room on full lock to use the tool the wheel will have to be removed, the tyre plugs can be used with the wheel in place, my intention is to use them on the road then remove the wheel and make a repair with the mushroom plug.
I started using plugs after paying a garagiste friend for a tyre repair, it took him all of 30 seconds and he only lost a tiny amount of air from the tyre in doing so. If you prepare the plug on the skewer needle and fit the rasp in a battery drill in advance you can then swiftly pull out the screw or nail, insert the rasp and prepare the hole then pull out with one hand while inserting the plug with the other then pull the skewer out which cuts through the doubled up plug sealing the hole, you lose only a tiny bit of air it does not even register on the pressure guage.
Easier to do swiftly with the wheel off the vehicle.
Did you know that tubeless tyres were originally sold as self sealing for punctures? I read the claims in a 1960's Readers Digest, the problem then as now with tubed tyres is that when they puncture there is an instantaneous total deflation which at speed causes loss of control and often the tyre to come off the rim, a puncture on a tubeless tyre is much slower and controlled, they demonstrated it by driving 2 vehicles with tubed and tubeless tyres over planks with 6" nails sticking out, the car on tubed tyres spun and rolled over , the other came to a controlled halt like you see on footage of a Police Stinger deployment but much slower and with full control.